A topology-based investigation of protein interaction sites using Hydrophobic Cluster Analysis

Study of PKA binding sites in cAMP-signaling pathway using structural protein-protein interaction networks

Backgroud: Protein-protein interaction, plays a key role in signal transduction in signaling pathways. Different approaches are used for prediction of these interactions including experimental and computational approaches. In conventional node-edge protein-protein interaction networks, we can only see which proteins interact but ‘structural networks’ show us how these proteins inter...

Prediction of Protein-protein Interaction Sites at Interface Topology Level

Protein-protein interactions play a crucial role in many biological processes such as immune response, enzyme catalysis, and signal transduction. Identifying the interacting sites between the proteins is important for understanding the functional mechanisms, and is crucial for drug development. Interaction profile hidden Markov model (ipHMM) was shown to be an effective tool for modeling protei...

Prediction of Protein Interaction Sites Using Mimotope Analysis

IntPred: a structure-based predictor of protein–protein interaction sites

Motivation Protein-protein interactions are vital for protein function with the average protein having between three and ten interacting partners. Knowledge of precise protein-protein interfaces comes from crystal structures deposited in the Protein Data Bank (PDB), but only 50% of structures in the PDB are complexes. There is therefore a need to predict protein-protein interfaces in silico and...

a gender-based pragmatic analysis of the use of english compliment responses by iraqi efl students:a speech act perspective

تعارفات کنش های گفتاری هستند که افراد در زندگی روزمر? خود به منظور برقراری دوستی یا تداوم روابط مسالمت آمیز به کار می برند. ساز و کار تعارف مختص زبان انگلیسی یا هر زبان دیگری نیست و پدیده ای است جهانی و در همه زبانها حضور دارد. تفاوتی که از این نظر در زبانها و فرهنگ ها وجود دارد مربوط به پاسخ به این کنش گفتاری در گفتمان است. این مطالعه به بررسی تنوع پاسخ های انگلیسی و عربی به کنش گفتاری تعارف د...